The susceptibility of Neisseria gonorrhoeae to cefoxitin sodium

Abstract

Minimum inhibitory concentrations (MICs) of cefoxitin sodium and benzylpenicillin for 48 gonococci were compared. Although benzylpenicillin was much more active on sensitive strains, the two agents similarly inhibited less-sensitive strains at a concentration of about 1 mg/1. Cefoxitin activity was not affected by the production of β-lactamase by 5β-lactamase-producing gonococci isolated in the U.K. and the U.S.A., but cephaloridine, cephalothin, cephalexin, cephradine, cefamandole, cefazolin, and cefuroxime were all less active against large than against small inocula. Despite this, cefuroxime was, weight for weight, more active than cefoxitin on large inocula.