Synthesis and antioxidant properties of some novel benzimidazole derivatives on lipid peroxidation in the rat liver
- 1 February 2004
- journal article
- Published by Springer Science and Business Media LLC in Archives of Pharmacal Research
- Vol. 27 (2), 156-163
- https://doi.org/10.1007/bf02980099
Abstract
Some benzimidazole derivatives namely 1-[(substituted thiocarbamoylhydrazine carbonyl) methyl]-2-phenyl-1H-benzimidazoles (1a-13a),N-[(2-phenylbenzimidazol-1-yl methyl)-[1,3,4]-thiadiazole-2-ylj-substituted phenyl amines (1b-13b) and 5-(2-phenyl benzimidazol-1-yl-methyl)-4-substituted phenyl-4H-1,2,4-triazole-3-thiones (1c-13c) were synthesized, and theirin vitro effects on the rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels were determined. The most active compound10a caused an 84% inhibition of LP at 10-3 M, which is better than that of butylated hydroxytoluene (BHT) (65%).Keywords
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