A paired sibling analysis of the beta-3 adrenergic receptor and obesity in Mexican Americans.
Open Access
- 1 February 1998
- journal article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 101 (3), 584-587
- https://doi.org/10.1172/jci512
Abstract
The beta3 adrenergic receptor, located on chromosome 8, is a regulator of energy expenditure and lipolysis. A missense mutation in this gene, characterized by the replacement of tryptophan by arginine at codon 64 (Trp64Arg), is associated with obesity in some studies. We examined the effect of this variant on obesity in Mexican Americans, using a paired sibling design to minimize variability due to genetic background and a previously identified major susceptibility locus for obesity. We identified 45 sib-pairs that were concordant (identical by descent) for a locus on chromosome 2 which we have shown previously to be tightly linked to obesity in this population. The Trp64Arg variant, detected by PCR-restriction fragment length polymorphism analysis, was present in one sibling within each of the 45 sib-pairs. Presence of the variant was associated with significantly higher values in body mass index (P = 0.04), fat mass (P = 0.04), and waist circumference (P = 0.05). We conclude that the Trp64Arg variant is associated with obesity in this Mexican American population. The paired sibling design probably enhanced our ability to detect the effects of this variant by allowing us to account for variation attributable to another obesity susceptibility locus and to background genes.Keywords
This publication has 25 references indexed in Scilit:
- A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2Nature Genetics, 1997
- Segregation analysis of fat mass and fat-free mass with age- and sex-dependent effects: The Stanislas family studyGenetic Epidemiology, 1997
- Beta 3-adrenergic receptor gene variant and lipid metabolism in Pima Indians.1997
- Role of the beta 3-adrenergic receptor locus in obesity and noninsulin-dependent diabetes among members of Caucasian families with a diabetic sibling pair.Journal of Clinical Endocrinology & Metabolism, 1996
- Influence of genotype-dependent effects of covariates on the outcome of segregation analysis of the body mass index.1993
- Segregation Analysis of Body Mass Index in an Unselected French‐Canadian Sample: The Québec Family StudyObesity Research, 1993
- Genetics of ObesityAnnual Review of Nutrition, 1993
- Segregation analysis of fat mass and other body composition measures derived from underwater weighing.1993
- The genetic and environmental sources of body mass index variability: the Muscatine Ponderosity Family Study.1991
- COMMON MAJOR GENE INHERITANCE OF EXTREME OVERWEIGHT1990