Craniofacial resection for malignant paranasal sinus tumors: Report of an International Collaborative Study
Top Cited Papers
- 11 April 2005
- journal article
- research article
- Published by Wiley in Head & Neck
- Vol. 27 (7), 575-584
- https://doi.org/10.1002/hed.20165
Abstract
Background. Malignant tumors of the superior sinonasal vault are rare, and, because of this and the varied histologic findings, most outcomes data reflect the experience of small patient cohorts. This International Collaborative study examines a large cohort of patients accumulated from multiple institutions experienced in craniofacial surgery, with the aim of reporting benchmark figures for outcomes and identifying patient‐related and tumor‐related predictors of prognosis after craniofacial resection (CFR). Methods. Three hundred thirty‐four patients from 17 institutions were analyzed for outcome. Patients with esthesioneuroblastoma were excluded and are being reported separately. The median age was 57 years (range, 3–98 years). One hundred eighty‐eight patients (56.3%) had had prior single‐modality or combined treatment, which included surgery in 120 (36%), radiation in 79 (23.7%), and chemotherapy in 56 (16.8%). The most common histologic findings were adenocarcinoma in 107 (32%) and squamous cell carcinoma in 101 (30.2%). The margins of resection were close or microscopically positive in 95 (30%). Adjuvant radiotherapy was given in 161 (48.2%) and chemotherapy in 16 (4.8%). Statistical analyses for outcomes were performed in relation to patient characteristics, tumor characteristics, including histologic findings and extent of disease, surgical resection margins, prior radiation, and prior chemotherapy to determine predictive factors. Results. Postoperative mortality occurred in 15 patients (4.5%). Postoperative complications occurred in 110 patients (32.9%). The 5‐year overall, disease‐specific, and recurrence‐free survival rates were 48.3%, 53.3%, and 45.8%, respectively. The status of surgical margins, histologic findings of the primary tumor, and intracranial extent were independent predictors of overall, disease‐specific, and recurrence‐free survival on multivariate analysis. Conclusions. CFR for malignant paranasal sinus tumors is a safe surgical treatment with an overall mortality of 4.5% and complication rate of 33%. The status of surgical margins, histologic findings of the primary tumor, and intracranial extent are independent predictors of outcome. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005Keywords
This publication has 19 references indexed in Scilit:
- Craniofacial surgery for malignant skull base tumorsCancer, 2003
- Sinonasal Undifferentiated Carcinoma: The Search for a Better OutcomeThe Laryngoscope, 2002
- Esthesioneuroblastoma: Reflections of a 21‐Year ExperienceThe Laryngoscope, 1999
- Cancer of the Nasal Cavity and Paranasal Sinuses:A Clinico-pathological Study of 277 PatientsActa Oncologica, 1997
- Craniofacial resection at the university of Virginia (1976‐1992): Survival analysisHead & Neck, 1994
- Treatment of paranasal sinus cancer with cranial base surgery: ResultsThe Laryngoscope, 1994
- Factors Influencing Survival in Ethmoid Sinus CancerJAMA Otolaryngology–Head & Neck Surgery, 1992
- PARANASAL SINUS CANCERAnz Journal of Surgery, 1991
- Prognostic factors in craniofacial surgeryThe Laryngoscope, 1991
- A combined intracranial facial approach to the paranasal sinusesThe American Journal of Surgery, 1963