Clinical experience in the use of cefuroxime in gonorrhoea.

Abstract

Cefuroxime, a new antibiotic derived from cephalosporin-C which is very stable in the presence of .beta.-lactamases produced by gram-negative organisms, was used to treat 856 male patients and 340 female patients with uncomplicated gonorrhea. In men the drug was used in 3 different doses, 1.5 g, 1 g and 750 mg plus 1 g probenecid; in women 1 g and 750 mg cefuroxime plus 1 g probenecid was used. Cure rates ranged from 94.8-99.3%. The antibiotic was well tolerated and was free from side effects. Cefuroxime would be a valuable and efficient substitute for penicillin in the treatment of gonorrhoea due to .beta.-lactamase-producing strains of gonococci.