Estrogen receptor cytochemistry in human breast cancer: Status and prospects
- 15 December 1981
- Vol. 48 (12), 2674-2686
- https://doi.org/10.1002/1097-0142(19811215)48:12<2674::aid-cncr2820481220>3.0.co;2-n
Abstract
Advances in knowledge of the endocrine control of neoplastic growth can be expected to stem directly from advances in pertinent techniques. Following this theme, the present paper describes how recent development in cytochemical techniques for estrogen receptors may maintain this expectation and lead to significant progress in the basic knowledge of breast cancer that can influence the treatment approach. Cytochemical techniques have shown that the binding of estrogen to target cells and tissues can be specifically visualized: moreover, estrogen binding sites characterized cytochemically under controlled conditions have proved to fulfill the accepted criteria for estrogen receptors. Some working solutions to basic questions concerning the tumor hormone-responsiveness have been provided and more precise explanations of fundamental growth-regulatory mechanisms are expected to emerge from the approach to breast cancer by cytologic endocrinology. However, in the present state of the art and in spite of tantalizing bits of data, cytochemical techniques for estrogen receptors do not seem extensible to routine purposes, as alternative to biochemical receptor assays in selecting patients for endocrine therapy. One must have strong reservations on their clinical use because of the almost complete lack of information about correlations of cytochemical results with the response to endocrine therapy. More studies evaluating the practical validity of estrogen receptor cytochemistry are required.This publication has 63 references indexed in Scilit:
- Intracellular flow of particulate steroidreceptor complexes in steroid target cellsVirchows Archiv B Cell Pathology Including Molecular Pathology, 1980
- A preliminary report on the use of immunoperoxidases to study binding of estrogens in rat uteriThe Journal of Steroid Biochemistry and Molecular Biology, 1979
- Receptors in Breast CancerNew England Journal of Medicine, 1978
- Therapeutic significance of sex-steroid hormone receptors in the treatment of breast cancerEuropean Journal of Cancer (1965), 1977
- A proposal for assessment of hormone sensitivity and consequent endocrine therapy of breast cancerEuropean Journal of Cancer (1965), 1977
- Human Breast Cancer: Biologically Active Estrogen Receptor in the Absence of Estrogen?Science, 1977
- Hormone dependency in breast cancerJournal of Steroid Biochemistry, 1976
- In vivo and in vitro immunofluorescent approach to the physiopathology of estradiol kinetics in target cellsJournal of Steroid Biochemistry, 1976
- 11. Microfluorimetric method to detect specific oestradiol receptors in different cell types or cell suspensions from target tissuesJournal of Steroid Biochemistry, 1975
- Predicting Response to Endocrine Therapy in Human Breast Cancer: A HypothesisScience, 1975