Early uncomplicated and localized idiopathic or nonspecific ulcerative colitis, I think, originates in early childhood, although the pathologic or pathologicphysiologic picture may not become evident until adolescent or adult life. The fact that the changes in the bowel wall begin for the most part in the rectum and sigmoid and spread upward to include the ascending limb of the splenic flexure has been passed over lightly in the discussion of this subject. There are many etiologic conceptions and varied therapeutic approaches. I have never been convinced that any specific organism is the cause. Five years ago I became interested in the increasing reports in psychiatric literature of presumable cure of uncomplicated and early ulcerative colitis. Psychiatrists claimed they could produce a lasting remission; this I consider a challenge. What did psychiatry accomplish that medicine could not? I could conclude only that the treatment had normalized the physiologic picture of the