Genetic programs regulating HSC specification, maintenance and expansion
- 20 September 2004
- journal article
- review article
- Published by Springer Science and Business Media LLC in Oncogene
- Vol. 23 (43), 7199-7209
- https://doi.org/10.1038/sj.onc.1207940
Abstract
All mature blood cells originate from a small population of self-renewing pluripotent hematopoietic stem cells (HSCs). The capacity to self-renew characterizes all stem cells, whether normal or neoplastic. Interestingly, recent studies suggest that self-renewal is essential for tumor cell maintenance, implicating that this process has therapeutic relevance. Unfortunately, the molecular bases for self-renewal of vertebrate cells remain poorly defined. This article will focus on the developmental mechanisms underlying fetal and adult HSC homeostasis. Specifically, distinctions between genetic programs regulating HSC specification (identity), self-renewal (in both fetal and adult) and differentiation/commitment will be discussed with a special emphasis on transcriptional and chromatin regulators.Keywords
This publication has 100 references indexed in Scilit:
- In vitro differentiation of c-myb−/− ES cells reveals that the colony forming capacity of unilineage macrophage precursors and myeloid progenitor commitment are c-Myb independentOncogene, 2000
- Initiation of adult myelopoiesis can occur in the absence of c-Myb whereas subsequent development is strictly dependent on the transcription factorOncogene, 2000
- Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cellNature Medicine, 1997
- The T Cell Leukemia Oncoprotein SCL/tal-1 Is Essential for Development of All Hematopoietic LineagesCell, 1996
- Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCLNature, 1995
- Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic LineagesScience, 1994
- TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasmsCell, 1991
- A functional c-myb gene is required for normal murine fetal hepatic hematopoiesisCell, 1991
- Developmental potential and dynamic behavior of hematopoietic stem cellsCell, 1986
- Loss of proliferative capacity in immunohemopoietic stem cells caused by serial transplantation rather than aging.The Journal of Experimental Medicine, 1978