This study examines a multifactorial model of caregiving strain and its effects in a sample of 341 employed caregivers, using a LISREL framework to estimate path coefficients. Work disruptions associated with caregiving significantly affected caregiving strain and the perceived likelihood of job termination. Work interference was in turn affected by the care recipient's level of impairment and the perceived adequacy of the support received. Respondents with more flexible job responsibilities reported lower levels of work interference than did other respondents.