Melatonin treatment for rhythm disorder
- 1 April 1998
- journal article
- case report
- Published by Wiley in Psychiatry and Clinical Neurosciences
- Vol. 52 (2), 262-263
- https://doi.org/10.1111/j.1440-1819.1998.tb01065.x
Abstract
We tried melatonin treatment in two patients with non-24 h sleep-wake syndrome, who did not respond to treatments by vitamin B12, bright light therapy, or hypnotics. In one patient, melatonin 5-10 mg improved difficulty in falling asleep and in waking, although it failed to improve the sleep-wake rhythm. In another patient, melatonin 3 mg successfully changed the sleep-wake rhythm from free-running pattern to delayed sleep phase pattern. However, melatonin re-administration after a 4-month drug-free interval failed to improve his free-running sleep-wake rhythm. These results suggest that melatonin acted as a sleep inducer in one patient and as a phase setter in the other, although the effect on the latter patient was transient.Keywords
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