Fluconazole once a week as secondary prophylaxis against oropharyngeal candidiasis in HIV‐infected patients: A double‐blind placebo‐controlled study
- 1 March 1993
- journal article
- clinical trial
- Published by AMPCo in The Medical Journal of Australia
- Vol. 158 (5), 312-316
- https://doi.org/10.5694/j.1326-5377.1993.tb121784.x
Abstract
To assess the efficacy and tolerance of fluconazole (150 mg oral dose, once a week) in the prevention of recurrent oropharyngeal candidiasis in patients with moderate to severe human immunodeficiency virus (HIV) infection. A randomised, double-blind, placebo-controlled trial. Eighty-four patients with moderate to severe HIV infection who had successfully completed two to four weeks treatment with fluconazole for oropharyngeal candidiasis were randomly allocated to receive either placebo or fluconazole. Pre-treatment clinical and laboratory characteristics were similar in the two groups. Success was classified as absence throughout the course of treatment of clinical evidence of oropharyngeal candidiasis, and failure as recurrence or relapse of symptomatic oropharyngeal candidiasis. Of 73 evaluable patients the median time to relapse was > or = 168 days in the fluconazole group and 37 days in the placebo group (P < 0.0001). One patient in the placebo group and 18 patients in the fluconazole group completed six months' treatment without clinical relapse (P < 0.001). Fluconazole was well tolerated and prevented clinical relapse of oropharyngeal candidiasis in 71% of patients who completed three months of treatment (95% confidence interval [CI], 55-86) and 58% (95% CI, 41-75) who completed six months of treatment.Keywords
This publication has 11 references indexed in Scilit:
- Primary prophylaxis with fluconazole against systemic fungal infections in HIV-positive patientsAIDS, 1992
- Fluconazole resistant candida in AIDSJournal of Infection, 1991
- Once-weekly fluconazole to prevent recurrence of oropharyngeal candidiasis in patients with AIDS and AIDS-related complex: A double-blind placebo-controlled studyJournal of Infection, 1990
- FluconazoleDrugs, 1990
- Drug Interactions with FluconazoleClinical Infectious Diseases, 1990
- Pharmacokinetics and Tissue Penetration of Fluconazole in HumansClinical Infectious Diseases, 1990
- COMPARISON OF FLUCONAZOLE AND KETOCONAZOLE FOR OROPHARYNGEAL CANDIDIASIS IN AIDSThe Lancet, 1989
- Pharmacokinetic study of the interaction between rifampicin and ketoconazoleJournal of Antimicrobial Chemotherapy, 1988
- Oral Candida albicans in HIV InfectionScandinavian Journal of Infectious Diseases, 1987
- Effect of ketoconazole on hepatic oxidative drug metabolismCancer Cell, 1985