Studies on the Biosynthesis of Iodotyrosines: The Relationship of Peroxidase, Catalase and Cytochrome Oxidase

Abstract

A comparison has been made of peroxidase, iodinase, catalase and cytochrome oxidase activity in sheep thyroid, liver, kidney, spleen and muscle tissue. A pyrogallol peroxidase is present in thyroid particles, but this activity does not parallel iodinating activity. Cytochrome oxidase is present in all the tissues, but the concentration of this enzyme does not correlate with iodinating activity. Catalase is abundant in liver and kidney and may in part explain the inability of these tissues to perform iodination. Soluble thyroidal iodide peroxidasetyrosine iodinase does not possess cytochrome oxidase activity.