Lipid Body–Phagosome Interaction in Macrophages during Infectious Diseases: Host Defense or Pathogen Survival Strategy?
Open Access
- 5 July 2012
- journal article
- review article
- Published by Public Library of Science (PLoS) in PLoS Pathogens
- Vol. 8 (7), e1002729
- https://doi.org/10.1371/journal.ppat.1002729
Abstract
Phagocytosis of invading microorganisms by specialized cells such as macrophages and neutrophils is a key component of the innate immune response. These cells capture and engulf pathogens and subsequently destroy them in intracellular vacuoles—the phagosomes. Pathogen phagocytosis and progression and maturation of pathogen-containing phagosomes, a crucial event to acquire microbicidal features, occurs in parallel with accentuated formation of lipid-rich organelles, termed lipid bodies (LBs), or lipid droplets. Experimental and clinical infections with different pathogens such as bacteria, parasites, and viruses induce LB accumulation in cells from the immune system. Within these cells, LBs synthesize and store inflammatory mediators and are considered structural markers of inflammation. In addition to LB accumulation, interaction of these organelles with pathogen-containing phagosomes has increasingly been recognized in response to infections and may have implications in the outcome or survival of the microorganism within host cells. In this review, we summarize our current knowledge on the LB-phagosome interaction within cells from the immune system, with emphasis on macrophages, and discuss the functional meaning of this event during infectious diseases.Keywords
This publication has 72 references indexed in Scilit:
- EicosaCell – An Immunofluorescent-Based Assay to Localize Newly Synthesized Eicosanoid Lipid Mediators at Intracellular SitesPublished by Springer Science and Business Media LLC ,2010
- Lipid Droplets Finally Get a Little R-E-S-P-E-C-TCell, 2009
- A Role for Lipid Bodies in the Cross-presentation of Phagocytosed Antigens by MHC Class I in Dendritic CellsImmunity, 2009
- PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid storesBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2009
- Phagosome maturation: going through the acid testNature Reviews Molecular Cell Biology, 2008
- Cytoplasmic lipid droplets are translocated into the lumen of the Chlamydia trachomatis parasitophorous vacuoleProceedings of the National Academy of Sciences, 2008
- Mycobacterial persistence requires the utilization of host cholesterolProceedings of the National Academy of Sciences, 2008
- Proteins under new management: lipid droplets deliverTrends in Cell Biology, 2007
- The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcγIIA receptor–induced phagocytosisThe Journal of Experimental Medicine, 2006
- Proteomic Analysis of Proteins Associated with Lipid Droplets of Basal and Lipolytically Stimulated 3T3-L1 AdipocytesJournal of Biological Chemistry, 2004