An instance of clinical radiation morbidity and cellular radiosensitivity, not associated with ataxia-telangiectasia
- 8 August 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in The British Journal of Radiology
- Vol. 63 (752), 624-628
- https://doi.org/10.1259/0007-1285-63-752-624
Abstract
A 14-year-old boy received standard induction chemotherapy for acute lymphoblastic leukaemia followed by standard dose cranial radiation prophylaxis (18 Gy). Severe chemosensitivity and acute radiation reactions occurred and he died at 8 months from late radiation damage. In vitro radiobiological studies of the boy's fibroblasts in culture demonstrated an enhanced radiosensitivity indistinguishable from ataxia-telangiectasia (A-T) cells. However, unlike A-T cells, DNA synthesis following irradiation was inhibited in a normal manner. This patient represents yet another example of extreme radiosensitivity, and the possibility of clinical prediction in the future is discussed.This publication has 21 references indexed in Scilit:
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