Facilitatory Role of Neuropeptide Y on the Onset of Puberty: Effect of Immunoneutralization of Neuropeptide Yon the Release of Luteinizing Hormone and Luteinizing-Hormone-Releasing Hormone
- 1 January 1990
- journal article
- research article
- Published by S. Karger AG in Neuroendocrinology
- Vol. 52 (1), 112-115
- https://doi.org/10.1159/000125548
Abstract
To examine the role of neuropeptide Y (NPY) in the first luteinizing hormone (LH) surge of puberty, the effect of passive immunoneutralization of NPY with antiserum against NPY (anti-NPY) injected centrally (third ventricle) or peripherally (jugular vein) was studied in pubertal female rats on the day of first proestrus. Both peripheral and central anti-NPY administration reduced the magnitude of the LH surge during the afternoon of first proestrus; however, the central route of administration appeared to be most effective. Centrally administered anti-NPY also reduced the magnitude of proestrous LH-releasing hormone (LHRH) release into pituitary portal blood in these rats. These results suggest that endogenous NPY plays a facilitatory role in the generation of the LHRH surge necessary for preovulatory gonadotropin release and puberty.Keywords
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