Segregation of Transcription and Replication Sites Into Higher Order Domains
- 4 September 1998
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 281 (5382), 1502-1505
- https://doi.org/10.1126/science.281.5382.1502
Abstract
Microscopy shows that individual sites of DNA replication and transcription of mammalian nuclei segregate into sets of roughly 22 and 16 higher order domains, respectively. Each domain set displayed a distinct network-like appearance, including regions of individual domains and interdigitation of domains between the two networks. These data support a dynamic mosaic model for the higher order arrangement of genomic function inside the cell nuclei.Keywords
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