Association cortex hypoperfusion in mild dementia with Lewy bodies: a potential indicator of cholinergic dysfunction?
- 6 October 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in Brain Imaging and Behavior
- Vol. 5 (1), 25-35
- https://doi.org/10.1007/s11682-010-9108-x
Abstract
Dementia with Lewy bodies (DLB) is often associated with occipital hypometabolism or hypoperfusion, as well as deficits in cholinergic neurotransmission. In this study, 11 mild DLB, 16 mild AD and 16 age-matched controls underwent arterial spin-labeled perfusion MRI (ASL-pMRI) and neuropsychological testing. Patterns of cerebral blood flow (CBF) and cognitive performance were compared. In addition, combined ASL-pMRI and ChEI drug challenge (pharmacologic MRI) was tested as a probe of cholinergic function in 4 of the DLB participants. Frontal and parieto-occipital hypoperfusion was observed in both DLB and AD but was more pronounced in DLB. Following ChEI treatment, perfusion increased in temporal and parieto-occipital cortex, and cognitive performance improved on a verbal fluency task. If confirmed in a larger study, these results provide further evidence for brain cholinergic dysfunction in DLB pathophysiology, and use of pharmacologic MRI as an in vivo measure of cholinergic function.Keywords
This publication has 45 references indexed in Scilit:
- Practical suggestions on how to differentiate dementia with Lewy bodies from Alzheimer's disease with common cognitive testsInternational Journal of Geriatric Psychiatry, 2009
- Continuous flow‐driven inversion for arterial spin labeling using pulsed radio frequency and gradient fieldsMagnetic Resonance in Medicine, 2008
- Hippocampal hyperperfusion in Alzheimer's diseaseNeuroImage, 2008
- Limitations of the HMPAO SPECT appearances of occipital lobe perfusion in the differential diagnosis of dementia with Lewy bodiesNuclear Medicine Communications, 2007
- Comparison of Regional Brain Volume and Glucose Metabolism Between Patients with Mild Dementia with Lewy Bodies and Those with Mild Alzheimer's DiseaseJournal of Nuclear Medicine, 2007
- Focal atrophy in dementia with Lewy bodies on MRI: a distinct pattern from Alzheimer's diseaseBrain, 2007
- The precuneus: a review of its functional anatomy and behavioural correlatesBrain, 2006
- Degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in Alzheimer's diseaseJournal of Neurology, Neurosurgery & Psychiatry, 2005
- The Mini‐Mental State exam may help in the differentiation of dementia with Lewy bodies and Alzheimer's diseaseInternational Journal of Geriatric Psychiatry, 2002
- Dementia with Lewy bodiesThe British Journal of Psychiatry, 2002