Biological Photochemistry. I. The Correlation between the Photodynamical Behaviors and the Chemical Structures of Nucleic Acid-bases, Nucleosides, and Related Compounds in the Presence of Methylene-blue

Abstract

As a study on mechanism of photo-dynamic action with methylene-blue, the authors examined structural correlation of 40 kinds of nucleic acid-bases, nucleosides and related compounds with their photodynamic degradation by visible light-irradiation in the presence of methylene-blue. As a result, it became established that 1) Above-mentioned compounds, in order to be easily photodynamically degradated, need to have the lactim structure with respect to N 1 and 3-position in pyrimidine moiety of purine ring. 2) Imidazol ring seems to be essential for photodegradation. 3) Existence of substituent in 8, 9-position in purine didn''t affect on photochemical reaction.