Retinal venous oxygen saturation and cardiac output during controlled hemorrhage and resuscitation
- 1 March 2003
- journal article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 94 (3), 891-896
- https://doi.org/10.1152/japplphysiol.01197.2001
Abstract
The objective was to test calibration of an eye oximeter (EOX) in a vitiligo swine eye and correlate retinal venous oxygen saturation (SrvO2), mixed venous oxygen saturation (SvO2), and cardiac output (CO) during robust changes in blood volume. Ten anesthetized adult Sinclair swine with retinal vitiligo were placed on stepwise decreasing amounts of oxygen. At each oxygen level, femoral artery oxygen saturation (SaO2) and retinal artery oxygen saturation (SraO2) were obtained. After equilibration on 100% O2, subjects were bled at 1.4 ml · kg−1· min−1for 20 min. Subsequently, anticoagulated shed blood was reinfused at the same rate. During graded hypoxia, exsanguination, and reinfusion, SraO2and SrvO2were measured by using the EOX, and CO and SvO2were measured by using a pulmonary artery catheter. During graded hypoxia, SraO2correlated with SaO2( r = 0.92). SrvO2correlated with SvO2( r = 0.89) during exsanguination and reinfusion. SvO2and SrvO2correlated with CO during blood removal and resuscitation ( r = 0.92). Use of vitiligo retinas improved the calibration of EOX measurements. In this robust hemorrhage model, SrvO2correlates with CO and SvO2across the range of exsanguination and resuscitation.Keywords
This publication has 45 references indexed in Scilit:
- Optical model of the blood in large retinal vesselsJournal of Biomedical Optics, 2000
- Retinal Venous Oxygen Saturation Correlates with Blood VolumeAcademic Emergency Medicine, 1998
- Sinclair miniature swine: an animal model of human melanomaVeterinary Immunology and Immunopathology, 1994
- Pulse Oximetry Is Accurate in Acute Anemia From HemorrhageAnnals of Emergency Medicine, 1994
- Hemodynamic responses to shock in young trauma PatientsCritical Care Medicine, 1994
- DISUSE RESISTANCE TO METOCURINEAnesthesiology, 1989
- Structural characteristics of the mammalian spleen indicating storage and release of red blood cells. Aspects of evolutionary and environmental demandsCellular and Molecular Life Sciences, 1985
- Studies of the Retinal Circulation in ManCell Metabolism, 1966
- A Study of Retinal Venous Blood Oxygen Saturation in Human Subjects by Photographic MeansCirculation, 1963
- SHANNON, E. W., AND GARDNER, W. J.Anesthesiology, 1946