Structural biology of Zika virus and other flaviviruses
- 8 January 2018
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Structural & Molecular Biology
- Vol. 25 (1), 13-20
- https://doi.org/10.1038/s41594-017-0010-8
Abstract
Zika virus (ZIKV) is an enveloped, icosahedral flavivirus that has structural and functional similarities to other human flavivirus pathogens such as dengue (DENV), West Nile (WNV) and Japanese encephalitis (JEV) viruses. ZIKV infections have been linked to fetal microcephaly and the paralytic Guillain–Barré syndrome. This review provides a comparative structural analysis of the assembly, maturation and host-cell entry of ZIKV with other flaviviruses, especially DENV. We also discuss the mechanisms of neutralization by antibodies.Keywords
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