Myths in the Treatment of Type 2 Diabetes
- 1 September 2013
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Clinical Journal of Sport Medicine
- Vol. 20 (5), 543-548
- https://doi.org/10.1097/mjt.0b013e31820159aa
Abstract
Numerous randomized control trials (RCTs) have now questioned the effectiveness and safety of several therapeutic interventions in type 2 diabetes (T2DM). Those RCTs that address several therapeutic interventions in T2DM were reviewed. Meta-analysis and ad hoc analysis were excluded. The data from those trials involving self-monitoring of blood glucose, treating hyperglycemia, lowering triglycerides, aggressive treatment of hypertension, and antiplatelet therapy with aspirin are presented with emphasis on hard end points. The evidence shows that self-monitoring of blood glucose, lowering blood glucose, reducing triglycerides, aggressive treatment of hypertension, and aspirin therapy are of questionable value in T2DM and may cause harm. Based on RCTs, most therapies in the treatment of T2DM are of questionable value. The medical community should reassess the usefulness of these therapies, which have become commonplace in the management of this condition.Keywords
This publication has 34 references indexed in Scilit:
- Evaluation of Self Monitoring of Blood Glucose in Non-Insulin-Treated Diabetic Patients by Randomized Controlled Trials: Little Bang for the BuckReviews on Recent Clinical Trials, 2010
- Treatment intensification in patients with type 2 diabetesDiabetes, Obesity and Metabolism, 2008
- Efficacy of self monitoring of blood glucose in patients with newly diagnosed type 2 diabetes (ESMON study): randomised controlled trialBMJ, 2008
- Effect of a Multifactorial Intervention on Mortality in Type 2 DiabetesNew England Journal of Medicine, 2008
- Impact of self monitoring of blood glucose in the management of patients with non-insulin treated diabetes: open parallel group randomised trialBMJ, 2007
- The effect of self monitoring of blood glucose concentrations on glycated hemoglobin levels in diabetic patients not taking insulin: A blinded, randomized trialAmerican Journal Of Medicine, 2005
- Self-monitoring of blood glucose significantly improves metabolic control in patients with type 2 diabetes mellitus: the Auto-Surveillance Intervention Active (ASIA) studyDiabetes & Metabolism, 2003
- Meal-Related Structured Self-Monitoring of Blood GlucoseDiabetes Care, 2002
- Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational studyBMJ, 2000
- Discrepancies between Meta-Analyses and Subsequent Large Randomized, Controlled TrialsNew England Journal of Medicine, 1997