Gastric Inhibition of the Drinking Response

Abstract

Intravenous injection of 20% NaCl in dogs augmented water drinking. This drinking response was significantly inhibited if the stomach was distended for 20-40 minutes with water or a balloon in the stomach. Water into the rectum 30-40 minutes preceding salt administration moderately depressed drinking. Gastric distention failed to inhibit drinking if maintained for only 5 minutes prior to salt administration or if cocaine was applied to the gastric mucosa. Drinking response was delayed for 1 hour if the stomach was distended for 40 minutes and then deflated at the time of salt administration.