In vivo activity of paromomycin against susceptible and multidrug-resistant Mycobacterium tuberculosis and M. avium complex strains
Open Access
- 1 February 1994
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 38 (2), 170-173
- https://doi.org/10.1128/aac.38.2.170
Abstract
Encouraged by in vitro results, we have assessed the in vivo activity of paromomycin (PRM) against Mycobacterium tuberculosis, multidrug-resistant (MDR) M. tuberculosis (resistant to isoniazid, rifampin, and streptomycin), and Mycobacterium avium complex in C57BL/6 mice and their beige counterparts. In all these experiments, PRM was effective in preventing mortality from a mycobacterial infection and was significantly more active than the drug-free control (P < 0.0005) in reducing the CFU relative to the mean log CFU in the lungs, livers, and spleens of infected animals. In the drug-susceptible M. tuberculosis experiment, PRM given at 100 and 200 mg/kg of body weight was significantly less active than isoniazid at 25 mg/kg (P < 0.0005) in reducing the mean log CFU in the lungs, livers, and spleens of infected mice. In the MDR M. tuberculosis experiment, PRM given at 200 mg/kg was effective, relative to the drug-free control, in reducing the mean log CFU of an isolate of M. tuberculosis resistant to isoniazid, rifampin, and streptomycin. In the M. avium complex experiment, PRM given at 200 mg/kg was as effective as amikacin at 50 mg/kg in reducing the mean log CFU in the lungs, livers, and spleens of infected mice. On the basis of our experiments, we believe that PRM has promising activity in vivo in the treatment of infections caused by M. tuberculosis, MDR M. tuberculosis, and M. avium complex.Keywords
This publication has 6 references indexed in Scilit:
- Incidence of Mycobacterium avium-intracellulare Complex Bacteremia in Human Immunodeficiency Virus-Positive PatientsThe Journal of Infectious Diseases, 1992
- Tuberculosis morbidity in the United States: final data, 1990.1991
- The Epidemiology of Disseminated Nontuberculous Mycobacterial Infection in the Acquired Immunodeficiency Syndrome (AIDS)American Review of Respiratory Disease, 1989
- Mycobacterium avium Complex Infections in Patients with the Acquired Immunodeficiency SyndromeAnnals of Internal Medicine, 1986
- The action of antituberculosis drugs in short-course chemotherapyTubercle, 1985
- THE EARLY BACTERICIDAL ACTIVITY OF DRUGS IN PATIENTS WITH PULMONARY TUBERCULOSISPublished by Elsevier BV ,1980