The effects of nontumor viruses on virus-induced leukemia in mice: reciprocal interference between Sendai virus and Friend leukemia virus in DBA-2 mice.

Abstract

Sendai virus inoculated into DBA/2 mice as long as 3 wk. prior to Friend virus reduced the splenomegalic response to Friend virus. This effect was dependent upon the route of inoculation: both viruses were administered intraperitoneally. Newcastle disease, vesicular stomatitis, and Sindbis viruses have no such Friend virus-inhibiting properties. Sendai virus inoculated into mice IP [intraperitoneally] induces the production in the peritoneal cavity of 103 culture protecting units of interferon within 24 hr. Within 1 day after Friend virus inoculation PI or IV [intravenous], mice undergo a marked reduction or peritoneal interferon response to Sendai virus. By 12 days after Friend virus inoculation, mice can once again synthesize normal amounts of interferon in response to Sendai virus. The interactions between these 2 viruses in the animal model may offer clues as to the development and suppression of human leukemia.