Is Anticancer Drug Development Heading in the Right Direction?
Open Access
- 12 February 2009
- journal article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 69 (4), 1259-1262
- https://doi.org/10.1158/0008-5472.can-08-3786
Abstract
The success of molecularly targeted agents, such as imatinib, has led to expectations of a new era in anticancer drug development, and to a greatly increased focus on targeting as a strategy. However, the number of successes to date is small, and recent results suggest that the success of imatinib, for instance, in treating chronic myelogenous leukemia and gastrointestinal stromal tumor may be the exception rather than the rule. Here, we argue that the search for new anticancer agents needs to continue on as many fronts as possible, and not be focused on one strategy alone. [Cancer Res 2009;69(4):1259–62]Keywords
This publication has 16 references indexed in Scilit:
- Cancer complexity slows quest for cureNature, 2008
- Comprehensive genomic characterization defines human glioblastoma genes and core pathwaysNature, 2008
- Kinase domain point mutations in Philadelphia chromosome‐positive acute lymphoblastic leukemia emerge after therapy with BCR‐ABL kinase inhibitorsCancer, 2008
- Physiological Targeting to Improve Anticancer Drug SelectivityAustralian Journal of Chemistry, 2008
- 'Clean' or 'Dirty' – Just How Selective Do Drugs Need To Be?Australian Journal of Chemistry, 2008
- Engineering tumors with 3D scaffoldsNature Methods, 2007
- The resurgence of platinum-based cancer chemotherapyNature Reviews Cancer, 2007
- Studies of a Cobalt(III) Complex of the MMP Inhibitor Marimastat: A Potential Hypoxia‐Activated ProdrugChemistry – A European Journal, 2007
- Stressed out heartsNature Reviews Drug Discovery, 2006
- The Design of Drugs that Target Tumour HypoxiaAustralian Journal of Chemistry, 2004