Friend or enemy? Review of 17β‐HSD10 and its role in human health or disease
Open Access
- 19 April 2020
- journal article
- review article
- Published by Wiley in Journal of Neurochemistry
- Vol. 155 (3), 231-249
- https://doi.org/10.1111/jnc.15027
Abstract
17β‐hydroxysteroid dehydrogenase (17β‐HSD10) is a multifunctional human enzyme with important roles both as a structural component and also as a catalyst of many metabolic pathways. This mitochondrial enzyme has important functions in the metabolism, development and aging of the neural system, where it is involved in the homeostasis of neurosteroids, especially in regard to estradiol, changes in which make it an essential part of neurodegenerative pathology. These roles therefore, indicate that 17β‐HSD10 may be a possible druggable target for neurodegenerative diseases including Alzheimer’s disease (AD), and in hormone dependent cancer. The objective of this review is to provide a summary about physiological functions and pathological roles of 17β‐HSD10 and the modulators of its activity.Keywords
Funding Information
- Ministerstvo Zdravotnictví Ceské Republiky (NV19‐09‐00578)
This publication has 157 references indexed in Scilit:
- The Amyloid-β-SDR5C1(ABAD) Interaction Does Not Mediate a Specific Inhibition of Mitochondrial RNase PPLOS ONE, 2013
- A 5-methylcytosine hotspot responsible for the prevalent HSD17B10 mutationGene, 2013
- HSD10 disease: clinical consequences of mutations in the HSD17B10 geneJournal of Inherited Metabolic Disease, 2011
- Hydroxysteroid (17β) dehydrogenase X in human health and diseaseMolecular and Cellular Endocrinology, 2011
- Cyclophilin D in mitochondrial pathophysiologyBiochimica et Biophysica Acta (BBA) - Bioenergetics, 2010
- A non‐enzymatic function of 17β‐hydroxysteroid dehydrogenase type 10 is required for mitochondrial integrity and cell survivalEMBO Molecular Medicine, 2010
- Estrogen receptor alpha interacts with 17β-hydroxysteroid dehydrogenase type 10 in mitochondriaBiochemical and Biophysical Research Communications, 2009
- RNase P without RNA: Identification and Functional Reconstitution of the Human Mitochondrial tRNA Processing EnzymeCell, 2008
- Submicroscopic Duplications of the Hydroxysteroid Dehydrogenase HSD17B10 and the E3 Ubiquitin Ligase HUWE1 Are Associated with Mental RetardationAmerican Journal of Human Genetics, 2008
- Clinical variability in 3-hydroxy-2-methylbutyryl-coa dehydrogenase deficiencyAnnals of Neurology, 2002