POSSIBLE ROLE OF GAMMA-AMINOBUTYRIC ACID SYNTHESIS IN THE MECHANISM OF DEXAMETHASONE FEEDBACK ACTION
- 1 April 1978
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 77 (1), 137-141
- https://doi.org/10.1677/joe.0.0770137
Abstract
Specific inhibition of glutamic acid decarboxylase (GAD, EC 4.1.1.15; the main enzyme involved in the synthesis of γ-aminobutyric acid) by mercaptopropionic acid interferes with the effect of dexamethasone on both the resting and stress-induced secretion of ACTH. It is postulated that dexamethasone may, at least in part, inhibit the secretion of ACTH via the induction of GAD, thereby raising the level of γ-aminobutyric acid in the central nervous system.This publication has 6 references indexed in Scilit:
- Glutamate decarboxylase (GAD) and γ-aminobutyric acid (GABA) in discrete nuclei of hypothalamus and substantia nigraBrain Research, 1977
- EARLY RESPONSE OF RAT BRAIN TRYPTOPHAN HYDROXYLASE ACTIVITY TO CYCLOHEXIMIDE, PUROMYCIN AND CORTICOSTERONEJournal of Neurochemistry, 1976
- REGIONAL DISTRIBUTION OF GLUTAMATE DECARBOXYLASE AND GABA WITHIN THE AMYGDALOID COMPLEX AND STRIA TERMINALIS SYSTEM OF THE RATJournal of Neurochemistry, 1976
- Distribution of glutamete decar☐ylase in discrete brain nucleiBrain Research, 1976
- CORTICOSTEROID RECEPTORS IN CENTRAL NERVOUS-SYSTEM OF RAT1975
- INDUCTION OF TYROSINE-ALPHA-KETOGLUTARATE TRANSAMINASE IN RAT LIVER .4. EVIDENCE FOR AN INCREASE IN RATE OF ENZYME SYNTHESIS1962