N-acetylcysteine for hepatic veno-occlusive disease after allogeneic stem cell transplantation
Open Access
- 26 April 2000
- journal article
- case report
- Published by Springer Science and Business Media LLC in Bone Marrow Transplantation
- Vol. 25 (9), 993-996
- https://doi.org/10.1038/sj.bmt.1702387
Abstract
Three patients developed veno-occlusive disease of the liver (VOD) after allogeneic stem cell transplantation. On the day after diagnosis, N-acetylcysteine (NAC) was given, initially in loading doses and thereafter 50–150 mg/kg/day for 12 to 31 days. The maximum bilirubin levels were 137, 58 and 138 mmol/l in the three patients, respectively. After the introduction of NAC, bilirubin, aspertate aminotransferase, sIL-2 receptor and IL-8 decreased. All three patients achieved normal bilirubin levels and prothrombin times. To conclude, NAC may be useful for treatment of VOD. Bone Marrow Transplantation (2000) 25, 993–996.Keywords
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