Pertussis toxin blocks angiotensin II‐induced calcium influx but not inositol trisphosphate production in adrenal glomerulosa cell
- 18 August 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 204 (2), 347-351
- https://doi.org/10.1016/0014-5793(86)80841-9
Abstract
Involvement of GTP‐binding proteins in angiotensin II‐induced mobilization of calcium has been examined in adrenal glomerulosa cells by using pertussis toxin. Pretreatment of glomerulosa cells with pertussis toxin abolishes angiotensin II‐induced calcium influx without blocking inositol trisphosphate production. These results suggest a role of the pertussis toxin‐sensitive GTP‐binding protein in transducing angiotensin II‐receptor occupancy into opening of calcium channel.Keywords
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