Electron Microscope Study of a Cell-Free Induced Leukemia of the Mouse: A Preliminary Report
Open Access
- 25 March 1958
- journal article
- research article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 4 (2), 151-156
- https://doi.org/10.1083/jcb.4.2.151
Abstract
Preliminary results of an electron microscope study of a leukemia of the mouse transmissible by cell-free filtrates are reported. In twelve out of forty-seven specimens examined, virus-like particles were observed. So far, these particles have not been observed in control, non-leukemic animals. They are located inside the cytoplasm of leukemic cells which infiltrate the spleen or the liver. Their diameter is approximately 78 mµ. Their resemblance to other particles recently described in different mouse tumors is stressed. Their significance and, in correlation with ultrafiltration data, their possible etiological meaning are discussed.Keywords
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