The Significance of Vascular and Neural Apoptosis to the Pathology of Diabetic Retinopathy
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Open Access
- 1 February 2011
- journal article
- review article
- Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Opthalmology & Visual Science
- Vol. 52 (2), 1156-1163
- https://doi.org/10.1167/iovs.10-6293
Abstract
The most striking features of diabetic retinopathy are the vascular abnormalities that are apparent by fundus examination. There is also strong evidence that diabetes causes apoptosis of neural and vascular cells in the retina. Thus, there is good reason to define diabetic retinopathy as a form of chronic neurovascular degeneration. In keeping with the gradual onset of retinopathy in humans, the rate of cell loss in the animal models is insidious, even in uncontrolled diabetes. This is not surprising given that a sustained high rate of cell loss without regeneration would soon lead to catastrophic tissue destruction. The consequences of ongoing cell death are difficult to detect, and even the quantification of cumulative cell loss requires painstaking histology and microscopy. This subtle cell loss raises the issue of the relevance of the phenomenon to the progression of diabetic retinopathy and the ultimate loss of vision. Neuronal function may be compromised in advance of apoptosis, contributing to an early deterioration of vision. Here we review some of the evidence supporting apoptotic cell death as a contributing mechanism of diabetic retinopathy, explore some of the potential causes, and discuss the potential links between apoptosis and loss of visual function in diabetic retinopathy.Keywords
This publication has 115 references indexed in Scilit:
- Matrix metalloproteinase-2 in the development of diabetic retinopathy and mitochondrial dysfunctionLaboratory Investigation, 2010
- Decreased Retinal Ganglion Cell Layer Thickness in Patients with Type 1 DiabetesInvestigative Opthalmology & Visual Science, 2010
- Resveratrol Inhibits Neuronal Apoptosis and Elevated Ca2+/Calmodulin-Dependent Protein Kinase II Activity in Diabetic Mouse RetinaDiabetes, 2010
- Neurodegenerative influence of oxidative stress in the retina of a murine model of diabetesDiabetologia, 2010
- Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathyNature Medicine, 2009
- Mitochondria and the regulation of free radical damage in the eyeJournal of Ocular Biology, Diseases, and Informatics, 2009
- Selective Loss of Inner Retinal Layer Thickness in Type 1 Diabetic Patients with Minimal Diabetic RetinopathyInvestigative Opthalmology & Visual Science, 2009
- Diabetes Reduces Autophosphorylation of Retinal Insulin Receptor and Increases Protein-Tyrosine Phosphatase-1B ActivityInvestigative Opthalmology & Visual Science, 2009
- TNF-α signaling in glaucomatous neurodegenerationSex Differences In The Human Brain, Their Underpinnings and Implications, 2008
- Whole genome assessment of the retinal response to diabetes reveals a progressive neurovascular inflammatory responseBMC Medical Genomics, 2008