Some effects of substance P on central respiratory control in rabbit pups
- 1 July 1985
- journal article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 124 (3), 449-455
- https://doi.org/10.1111/j.1748-1716.1985.tb07681.x
Abstract
Respiratory effects of substance P (SP) have been studied in rabbit pups (I-30 days). Rabbits were either anaesthetized with urethane or decerebrated at mid-collicular level. Respiratory activity was measured with a pneumotachograph or in some cases as efferent phrenic nerve activity. SP applied to the exposed medulla oblongata from the dorsal side caused an increase of both tidal volume and respiratory frequency. The respiratory stimulation was more pronounced in decerebrate animals than in anesthetized ones. Moreover, this effect was most prominent in the youngest animals. A SP analogue (D-Arg1-D-Pro2, D-Trp7,9, Leu11)-SP was found to block the ventilatory effects of SP and to decrease the hypoxic response, while the hypercapnic response was preserved. The results suggest that SP is involved in the control of respiration, possibly mediating the hypoxic response, and that this role is more important in the neonatal period.Keywords
This publication has 16 references indexed in Scilit:
- Post-mortem analyses of neuropeptides in brains from sudden infant death victimsBrain Research, 1984
- On the central pattern generator for the basic breathing rhythmicityJournal of Applied Physiology, 1983
- Immediate changes in ventilation and respiratory pattern associated with onset and cessation of locomotion in the cat.The Journal of Physiology, 1983
- Breathing in fetal lambs: the effect of brain stem section.The Journal of Physiology, 1983
- Evidence suggesting a role for Substance P in central respiratory regulation in the ratActa Physiologica Scandinavica, 1981
- Substance P as a baro- and chemoreceptor afferent neurotransmitter: Immunocytochemical and neurochemical evidence in the ratPeptides, 1980
- Evidence that substance P is a neurotransmitter of baro- and chemoreceptor afferents in nucleus tractus solitariusBrain Research, 1980
- Evidence suggesting a transmitter or neuromodulatory role for substance P at the first synapse of the baroreceptor reflexNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1980
- Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminalsNeuroscience, 1978
- Neurotropic Effects of Substance PActa Physiologica Scandinavica, 1956