Cerebral Microbleeds on MR Imaging: Comparison between 1.5 and 7T
Open Access
- 5 May 2011
- journal article
- research article
- Published by American Society of Neuroradiology (ASNR) in American Journal Of Neuroradiology
- Vol. 32 (6), 1043-1049
- https://doi.org/10.3174/ajnr.a2450
Abstract
BACKGROUND AND PURPOSE: The detection of microbleeds differs strongly between studies, due to differences in scan protocol. This study aims to compare the visualization of microbleeds with 3D T2*-weighted imaging at 1.5T with 3D dual-echo T2*-weighted imaging at 7T. MATERIALS AND METHODS: Thirty-four patients (29 male; mean age, 58 ± 12 years) with atherosclerotic disease from the Second Manifestations of ARTerial Disease study were included. 3D T2*-weighted imaging at 1.5T and dual-echo T2*-weighted imaging at 7T were done in all patients. The presence and number of definite microbleeds were recorded on minimal intensity projections. Inter- and intraobserver reliability was assessed with Cohen κ test and the ICC. The difference in presence and number of microbleeds was tested with the McNemar test and Wilcoxon signed rank test. RESULTS: The interobserver ICC at 7T was 0.61 and the intraobserver ICC was 0.94, whereas at 1.5T the interobserver ICC was 0.50 and the intraobserver ICC was 0.59. Microbleeds were detected in significantly more patients on 7T (50%) than on 1.5T scans (21%) (P = .001). The number of microbleeds was also higher at 7T (median, 0.5; range, 0–5) than on 1.5T (median, 0.0; range, 0–6) (P = .002). CONCLUSIONS: 3D dual-echo T2*-weighted imaging at 7T results in better and more reliable detection of microbleeds compared with 3D T2*-weighted imaging at 1.5T.Keywords
This publication has 35 references indexed in Scilit:
- Cerebral microbleeds: a guide to detection and interpretationThe Lancet Neurology, 2009
- Microbleeds in Moyamoya Disease: Susceptibility-Weighted Imaging Versus T2*-Weighted Imaging at 3 TeslaInvestigative Radiology, 2008
- Prevalence and risk factors of cerebral microbleedsNeurology, 2008
- B leeding R isk A nalysis in S troke I maging Before Thrombo L ysis (BRASIL)Stroke, 2007
- Cerebral Microbleeds Are Associated With Lacunar Stroke Defined Clinically and Radiologically, Independently of White Matter LesionsStroke, 2006
- Prevalence and severity of microbleeds in a memory clinic settingNeurology, 2006
- Cerebral microbleeds on MRINeurology, 2006
- Asymptomatic microbleeds in moyamoya disease: T2*-weighted gradient-echo magnetic resonance imaging studyJournal of Neurosurgery, 2005
- Cerebral MicrobleedsStroke, 2004
- Cerebral Microbleeds in CADASILStroke, 2002