Seven postmenopausal women were treated for 28 days with a contraceptive drug. This clearly resulted in hepatic dysfunction in every patient, as judged by elevation of serum transaminase levels. The progestogen component of the drug was without effect in the 2 patients studied, and in 1 out of 3 cases treated with the estrogen component of the drug changes in hepatic function similar to those produced by the whole drug were observed.