Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications
Top Cited Papers
Open Access
- 26 February 2018
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Chemical Society Reviews
- Vol. 47 (10), 3574-3620
- https://doi.org/10.1039/c7cs00877e
Abstract
Peptide– and protein–nanoparticle conjugates have emerged as powerful tools for biomedical applications, enabling the treatment, diagnosis, and prevention of disease. In this review, we focus on the key roles played by peptides and proteins in improving, controlling, and defining the performance of nanotechnologies. Within this framework, we provide a comprehensive overview of the key sequences and structures utilised to provide biological and physical stability to nano-constructs, direct particles to their target and influence their cellular and tissue distribution, induce and control biological responses, and form polypeptide self-assembled nanoparticles. In doing so, we highlight the great advances made by the field, as well as the challenges still faced in achieving the clinical translation of peptide- and protein-functionalised nano-drug delivery vehicles, imaging species, and active therapeutics.Funding Information
- Wellcome Trust (098411/Z/12/Z)
- Stiftelsen för Strategisk Forskning (SSF 4-3713/2016)
- Vetenskapsrådet (VR 4-478/2016)
- Rosetrees Trust
- GlaxoSmithKline (Imperial College London Engineered Medicines Labor)
- FP7 Ideas: European Research Council (Naturale CG 616417)
- Engineering and Physical Sciences Research Council (EP/K020641/1, EP/K031953/1)
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