The Relations between the Antinuclear, Rheumatoid and L.E.-Cell Factors in the Systemic Rheumatic Diseases

Abstract

INTEREST in the pathophysiology of the systemic rheumatic diseases has been revitalized by the discovery of the serum factors that produce the L.E. cell in disseminated lupus erythematosus and the agglutination of sheep cells or latex particles in rheumatoid arthritis and the factors that, with the use of the fluorescent-antibody technic, have been shown to bind to cell nuclei or their components. These factors have been shown to be globulins^{1 2 3 4 5 6 7} and have been thought to be relatively specific for the various pathologic states. In fact, as time has passed, what were at first described as interesting findings in patients with . . .