Role of gastrointestinal hormones in the response to massive resection of the small bowel.
Open Access
- 1 November 1977
- Vol. 18 (11), 877-881
- https://doi.org/10.1136/gut.18.11.877
Abstract
Hypersecretion of gastric acid and accelerated intestinal transit are largely unexplained consequences of massive resection of the small bowel; several postulated humoral mechanisms remain unsubstantiated. The purpose of the study was to investigate the effects of 75% resection of the distal small bowel in dogs on circulating levels of a range of gastrointestinal hormones. Basal and meal-stimulated concentrations of insulin, secretin, gastrin, pancreatic glucagon, and total glucagon-like immunoreactivity (GLI) were measured by radioimmunoassay techniques. After resection, significant depletions of basal and stimulated total GLI (p less than 0.05 -- p less than 0.001) and a significant rise of stimulated gastrin (p less than 0.05) were discovered. These hormonal alterations may produce an important imbalance of humoral influences on gastrointestinal function. It is suggested that these changes may hold a key to the aetiology of the complications of massive resection of the small bowel.This publication has 21 references indexed in Scilit:
- Small bowel resection and gastric acid hypersecretion.Gut, 1974
- The Effects of Triglyceride Absorption upon Glucagon, Insulin, and Gut Glucagon-Like ImmunoreactivityJCI Insight, 1973
- Neural Regulation of Insulin Secretion in the DogJCI Insight, 1973
- An enteroglucagon tumourGut, 1972
- The Effect of Glucagon on Intestinal Motility and Blood FlowActa Physiologica Scandinavica, 1971
- GASTRIC ACID SECRETION IN CROHN'S DISEASE IN RELATION TO DISEASE ACTIVITY AND BOWEL RESECTIONThe Lancet, 1971
- The antral Hormone Gastrin: Physiological Properties of a Series of Synthetic Peptides structurally related to Gastrin INature, 1964
- Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific ActivityNature, 1962
- The Metabolic Effects of Intestinal Resection in ManPublished by Oxford University Press (OUP) ,1961
- AN EXPERIMENTAL EVALUATION OF THE NUTRITIONAL IMPORTANCE OF PROXIMAL AND DISTAL SMALL INTESTINEAnnals of Surgery, 1954