Use of Preoperative Breast Ultrasonography for Mapping of Breast Cancer Extent Improves Resection Margins During Breast Conservation Surgery
- 1 August 2004
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Surgery
- Vol. 139 (8), 863-869
- https://doi.org/10.1001/archsurg.139.8.863
Abstract
Background Positive margins after breast conservation surgery occur frequently and negatively influence local control rates. Hypothesis Preoperative breast ultrasonography reduces the incidence of positive margins during breast conservation surgery. Design Case-control analysis. Patients and Intervention One hundred twenty-two consecutive patients with invasive breast cancer were studied. Palpation or needle-wire–guided breast conservation surgery was used in the first 61 patients (group 1). Preoperative breast ultrasonography was added to the protocol in the last 61 patients (group 2). Main Outcome Measures Incidence of positive margins, distance to closest margin. Results There was a 3.7-fold reduction in positive margins (P = .04, 95% confidence interval, 1.06-16.73) and improved resection margins (P = .04, 95% confidence interval, 0.14-3.88) when breast ultrasonography was used. Reexcision of margins was done in 11% (7 of 61 patients) in group 1 and 3% (2 of 61 patients) in group 2 (P = .17). Conclusion Preoperative breast ultrasonography improves the margins of resection and decreases the incidence of positive margins during breast conservation surgery.Keywords
This publication has 20 references indexed in Scilit:
- Surgical margins in patients with early-stage breast cancer treated with breast conservation therapyThe American Journal of Surgery, 2002
- Twenty-Year Follow-up of a Randomized Trial Comparing Total Mastectomy, Lumpectomy, and Lumpectomy plus Irradiation for the Treatment of Invasive Breast CancerNew England Journal of Medicine, 2002
- Twenty-Year Follow-up of a Randomized Study Comparing Breast-Conserving Surgery with Radical Mastectomy for Early Breast CancerNew England Journal of Medicine, 2002
- Intraoperative Ultrasound Is Associated With Clear Lumpectomy Margins for Palpable Infiltrating Ductal Breast CancerAnnals of Surgery, 2001
- Factors Determining Outcome for Breast-Conserving Irradiation with Margin-Directed Dose Escalation to the Tumor BedInternational Journal of Radiation Oncology*Biology*Physics, 1998
- Breast conserving surgery for invasive breast cancer: Risk factors for ipsilateral breast tumor recurrencesBreast Cancer Research and Treatment, 1997
- The importance of the resection margin in conservative surgery for breast cancerEuropean Journal of Surgical Oncology, 1996
- Ten-Year Results of a Comparison of Conservation with Mastectomy in the Treatment of Stage I and II Breast CancerNew England Journal of Medicine, 1995
- Breast conservation treatment of early stage breast cancer: patterns of failureInternational Journal of Radiation Oncology*Biology*Physics, 1995
- Local Failure and Margin Status in Early-Stage Breast Carcinoma Treated with Conservation Surgery and Radiation TherapyAnnals of Surgery, 1993