Interspecies differences in systemic drug availability following subscutaneous pulsatile administration in cattle, sheep, dogs, and rats
- 1 June 1994
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research
- Vol. 28 (6), 713-722
- https://doi.org/10.1002/jbm.820280608
Abstract
Rats, dogs, sheep, and cattle were implanted subcutaneously with stainless‐steel tissue cages. Bolus injections of cefoxitin and ivermectin were administered to the interiors of the tissue cages 11, 32, and 60 days after implantation to simulate pulsatile drug release from an implanted device. Plasma drug levels were determined for 6 h for cefoxitin and up to 8 days for ivermectin. Tissue cages were retrieved 3 and 6 months after implantation for macroscopic and microscopic examination. In dogs and rats, plasma levels of both drugs following administrations to the tissue cages were significantly lower than those following subcutaneous injection, suggesting that the tissue growth around and in the cages posed a barrier to systemic drug availability in those species. In cattle and sheep, the tissue cages and associated tissue did not inhibit systemic availability of either drug as compared with routine subcutaneous administration. © 1994 John Wiley & Sons, Inc.Keywords
This publication has 18 references indexed in Scilit:
- Pulsatile and delayed release of lysozyme from ointment-like poly(ortho esters)Journal of Controlled Release, 1992
- A biodegradable delivery system for peptides: preclinical experience with the gonadotrophin-releasing hormone agonist ZoladexJournal of Controlled Release, 1992
- Pharmacokinetic and pharmacodynamic basis for peptide drug delivery system designJournal of Controlled Release, 1992
- Pharmacokinetic and pharmacodynamic aspects of polypeptide deliveryJournal of Controlled Release, 1990
- Pulsatile Insulin Delivery is More Efficient Than Continuous Infusion in Modulating Islet Cell Function in Normal Subjects and Patients with Type 1 DiabetesJournal of Clinical Endocrinology & Metabolism, 1988
- Prominent Orcadian Absorption of Intranasal Salmon Calcitonin (SCT) in Healthy SubjectsChronobiology International, 1988
- Pulsatile Administration of Human Corticotropin-Releasing Hormone in Patients with Secondary Adrenal Insufficiency: Restoration of the Normal Cortisol Secretory PatternJournal of Clinical Endocrinology & Metabolism, 1986
- Intravenous growth hormone: growth responses to patterned infusions in hypophysectomized ratsJournal of Endocrinology, 1985
- In vivo biocompatibility studies. I. The cage implant system and a biodegradable hydrogelJournal of Biomedical Materials Research, 1983
- The role of the fibrous capsule in the function of implanted drug‐polymer sustained release systemsJournal of Biomedical Materials Research, 1981