Aging, Resistance Training, and Diabetes Prevention
Open Access
- 1 January 2011
- journal article
- Published by Hindawi Limited in Journal of Aging Research
- Vol. 2011, 1-12
- https://doi.org/10.4061/2011/127315
Abstract
With the aging of the baby-boom generation and increases in life expectancy, the American population is growing older. Aging is associated with adverse changes in glucose tolerance and increased risk of diabetes; the increasing prevalence of diabetes among older adults suggests a clear need for effective diabetes prevention approaches for this population. The purpose of paper is to review what is known about changes in glucose tolerance with advancing age and the potential utility of resistance training (RT) as an intervention to prevent diabetes among middle-aged and older adults. Age-related factors contributing to glucose intolerance, which may be improved with RT, include improvements in insulin signaling defects, reductions in tumor necrosis factor-α, increases in adiponectin and insulin-like growth factor-1 concentrations, and reductions in total and abdominal visceral fat. Current RT recommendations and future areas for investigation are presented.Keywords
Funding Information
- National Institutes of Health (K01KD075424, R01DK082383)
This publication has 138 references indexed in Scilit:
- Body Fat Distribution and Inflammation Among Obese Older Adults With and Without Metabolic SyndromeObesity, 2010
- Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalencePopulation Health Metrics, 2010
- Resistance exercise volume affects myofibrillar protein synthesis and anabolic signalling molecule phosphorylation in young menThe Journal of Physiology, 2010
- Influence of exercise intensity in older persons with unchanged habitual nutritional intake: skeletal muscle and endocrine adaptationsAGE, 2010
- Age‐related differences in the dose–response relationship of muscle protein synthesis to resistance exercise in young and old menThe Journal of Physiology, 2009
- Metabolic flexibility and insulin resistanceAmerican Journal of Physiology-Endocrinology and Metabolism, 2008
- Whole-body skeletal muscle mass is not related to glucose tolerance or insulin sensitivity in overweight and obese men and womenApplied Physiology, Nutrition, and Metabolism, 2008
- Role of Mitochondrial Dysfunction in Insulin ResistanceCirculation Research, 2008
- Grip strength and the metabolic syndrome: findings from the Hertfordshire Cohort StudyQJM: An International Journal of Medicine, 2007
- Physical activity patterns assessed by accelerometry in older peopleEuropean Journal of Applied Physiology, 2006