Regional Distribution of Neurotensin in Human Brain
- 1 June 1982
- journal article
- Published by Wiley in Journal of Neurochemistry
- Vol. 38 (6), 1777-1780
- https://doi.org/10.1111/j.1471-4159.1982.tb06664.x
Abstract
Neurotensin (NT) is an endogenous neuropeptide that is active in many preclinical screening tests for neuroleptic drugs. Using a radioimmunoassay, we have studied the regional distribution of NT in postmortem human brain and in cerebrospinal fluid. Highest levels were present in the hypothalamus, substantia nigra, and limbic areas, whereas much lower amounts were found in the cortex and striatum. The chromatographic properties of hypothalamic immunoreactivity on ion-exchange and high pressure liquid chromatography were similar to those of the synthetic tridecapeptide. We conclude that NT is present in human brain with a distribution resembling that seen in other species, such as rat and monkey.Keywords
This publication has 15 references indexed in Scilit:
- Reduction in cholecystokinin-like immunoreactivity in the basal ganglia in Huntington's diseaseBrain Research, 1980
- Neurotensin: central nervous system effects of a neuropeptideTrends in Neurosciences, 1980
- The action of neurotensin on neurones in the nucleus accumbens and cerebellum of the ratGeneral Pharmacology: The Vascular System, 1979
- Regional distribution of methionine-enkephalin- and beta-endorphin-like immunoreactivity in human brain and pituitaryBrain Research, 1979
- AN ANALYSIS OF FACTORS INFLUENCING MEASUREMENTS OF DOPAMINE, NORADRENALINE, GLUTAMATEDECARBOXYLASE AND CHOLINE ACETYLASE IN HUMAN POST-MORTEM BRAIN TISSUEBrain, 1979
- Neurotensin, a biologically active peptideLife Sciences, 1978
- Calcium-dependent release of somatostatin and neurotensin from rat brain in vitroNature, 1978
- Neurotensin, a central nervous system peptide: apparent receptor binding in brain membranesBrain Research, 1977
- Regional distribution of neurotensin and somatostatin in rat brainBrain Research, 1977
- Regional and subcellular distributions of brain neurotensinLife Sciences, 1976