STEROID HORMONE INTERACTIONS AS EVIDENCED BY MODIFICATION OFβ-GLUCURONIDASE ACTIVITY OF THE PREPUTIAL GLANDS OF THE RAT12

Abstract

Beta-glucuronidase activity in the preputial gland of the rat was observed to be sharply depressed 14-17 days following ovariectomy. Estrogen treatment in acute expts. effected restoration to precastration levels. A sharp distinction was observed between those adrenal steroids capable of blocking this manifestation of estrogenic activity (compounds F and E) and those closely related materials which were ineffective in this regard (DCA, progesterone, pregnenolone and testosterone).