Stimulation of Erythropoiesis in Sublethally Irradiated Rats by a Plasma Factor.

Abstract

Single intravenous injections of plasma from anemic donor rats increased erythropoiesis in sublethally irradiated rats when compared with plasma from normal rats. Differences in erythropoiesis were measured by Fe59 incorporation into red cells and were statistically significant in 5 of 6 consecutive experiments. The factor in anemic plasma responsible for stimulation of erythropoiesis was stable on storage at -20[degree] and was not dialyzable. Use of the sublethally irradiated rat as a test animal for study of regulation of erythropoiesis is suggested.