Pathogenesis of experimental pulmonary alveolar proteinosis
Open Access
- 1 March 1970
- Vol. 25 (2), 230-236
- https://doi.org/10.1136/thx.25.2.230
Abstract
Rats exposed to various airborne dusts developed a condition identical to pulmonary alveolar proteinosis as seen in man. The experimental condition developed through a stage of endogenous lipid pneumonia, characterized by numerous large foamy macrophages widely distributed throughout the lung. These cells broke down to release a finely granular material which finally condensed to reproduce the appearances of alveolar proteinosis. Electron microscopy indicated that the alveolar material was produced by type II pneumocytes and may therefore represent pulmonary surfactant. A study of the dust-handling mechanism showed that in affected animals macrophage mobility was seriously impaired.Keywords
This publication has 12 references indexed in Scilit:
- Experimental “Acute” SilicosisArchives of environmental health, 1968
- Pulmonary alveolar proteinosis: Nature and origin of alveolar lipidAmerican Journal Of Medicine, 1968
- Silicosis and alveolar proteinosis.BMJ, 1967
- Atypical Reaction to Inhaled SilicaNature, 1967
- Multifocal histiocytosis in the lungs of ratsThe Journal of Pathology and Bacteriology, 1966
- Pulmonary lipidosis in laboratory rats.1965
- Genetic Relationship between Maximum Hematocrit Values and Hemoglobin Type in SheepScience, 1964
- Pulmonary Alveolar Cell Inclusions: Their Development in the RatScience, 1964
- Alveolar Epithelial Cell Mitochondria as Source of the Surface-Active Lung LiningScience, 1962
- Pulmonary Alveolar ProteinosisNew England Journal of Medicine, 1958