Superoxide anion-generating activity of polymorphonuclear leukocytes and monocytes in patients with lung cancer
Open Access
- 1 April 1992
- Vol. 69 (7), 1682-1687
- https://doi.org/10.1002/1097-0142(19920401)69:7<1682::aid-cncr2820690707>3.0.co;2-n
Abstract
Superoxide anion (O2−) production by polymorphonuclear leukocytes (PMN) and monocytes (MN) was measured in the peripheral blood of 70 patients with lung cancer. The O2− production by these cells was decreased in many, but not all, patients. The incidence of patients with lower O2− production increased as the stage advanced. The correlation between O2− production by these cells and peripheral blood smears was evaluated in patients with cancer. Patients with 80% granulocytes and 40% monocytes or more in their peripheral blood had a significantly lower O2− production by PMN and MN compared with those with less than 80% granulocytes and 40% monocytes, respectively. These results indicate that an abnormally increased number of granulocytes and monocytes in the peripheral blood of patients with cancer may depress immunoregulatory function. In addition, decreased O2− production by these cells should be considered when assessing the defense mechanisms and susceptibility to infection of these patients.Keywords
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