The metabolic chiral inversion of 2−arylpropionic acids–-A novel route with pharmacological consequences–-a correction

Abstract

In our recent review (Hutt & Caldwell 1983) on the metabolic chiral inversion of the 2−aryl propionic acids, Fig. 1 presented flying wedge diagrams to depict the three-dimensional structures of the enantiomers, assigned according to Shen (1979). Close examination of the Figure, in the light of model building, reveals that the absolute configurational designation of these structures is incorrect and should be reversed, i.e. the enantiomer labelled by us as R(-) is in fact S(+) and vice versa. We apologise for this error, and would also point out that the diagram of Shen (1979) upon which our assignments were based is similarly incorrect.