POTENTIAL TOXICITY OF NONREGULATED ASBESTIFORM MINERALS: BALANGEROITE FROM THE WESTERN ALPS. PART 3: DEPLETION OF ANTIOXIDANT DEFENSES
- 1 January 2005
- journal article
- research article
- Published by Informa UK Limited in Journal of Toxicology and Environmental Health, Part A
- Vol. 68 (1), 41-49
- https://doi.org/10.1080/15287390590523957
Abstract
The asbestiform fibrous silicate balangeroite exhibits cytotoxic and oxidative properties similar to those exerted by crocidolite asbestos. In human lung epithelial cells A549, balangeroite, like crocidolite, inhibited the pentose phosphate pathway (PPP), one of the main antioxidant intracellular tools; this inhibition was exerted also when PPP was activated by the redox-cycling compound menadione. PPP inhibition may be accounted for by the inhibition of its rate-limiting enzyme, glucose-6-phosphate dehydrogenase (G6PD). Reduced glutathione (GSH), the most important intracellular antioxidant molecule, was decreased by both balangeroite and crocidolite incubation. This effect was not related to any increased content of oxidized glutathione, or to any enhanced efflux of glutathione, suggesting that balangeroite fibers, like crocidolite, might favor the reaction of GSH with other molecules.Keywords
This publication has 14 references indexed in Scilit:
- POTENTIAL TOXICITY OF NONREGULATED ASBESTIFORM MINERALS: BALANGEROITE FROM THE WESTERN ALPS. PART 1: IDENTIFICATION AND CHARACTERIZATIONJournal of Toxicology and Environmental Health, Part A, 2005
- Long and short fiber amosite asbestos alters at a different extent the redox metabolism in human lung epithelial cellsToxicology and Applied Pharmacology, 2003
- Ascorbic Acid Modifies the Surface of Asbestos: Possible Implications in the Molecular Mechanisms of ToxicityChemical Research in Toxicology, 2003
- Crocidolite asbestos inhibits pentose phosphate oxidative pathway and glucose 6-phosphate dehydrogenase activity in human lung epithelial cellsFree Radical Biology & Medicine, 2002
- Iron inhibits the nitric oxide synthesis elicited by asbestos in murine macrophagesFree Radical Biology & Medicine, 2001
- Depletion of glutathione and ascorbate in lung lining fluid by respirable fibresAnnals of Work Exposures and Health, 2000
- The molecular basis of asbestos induced lung injuryThorax, 1999
- Regulation of Nitric Oxide Synthase Induction by Iron and Glutathione in Asbestos-Treated Human Lung Epithelial CellsArchives of Biochemistry and Biophysics, 1998
- Activation of alveolar macrophages and peripheral red blood cells in rats exposed to fibers/particlesToxicology Letters, 1998
- Intracellular Restraint: A New Basis for the Limitation in Response to Oxidative Stress in Human Erythrocytes Containing Low-Activity Variants of Glucose-6-Phosphate DehydrogenaseProceedings of the National Academy of Sciences, 1974