Review of evidence for immune evasion and persistent infection in Lyme disease
Open Access
- 1 April 2013
- journal article
- review article
- Published by Informa UK Limited in International Journal of General Medicine
- Vol. ume 6, 291-306
- https://doi.org/10.2147/ijgm.s44114
Abstract
Review of evidence for immune evasion and persistent infection in Lyme disease Keith Berndtson Park Ridge MultiMed, Park Ridge, IL, USA Is chronic illness in patients with Lyme disease caused by persistent infection? Three decades of basic and clinical research have yet to produce a definitive answer to this question. This review describes known and suspected mechanisms by which spirochetes of the Borrelia genus evade host immune defenses and survive antibiotic challenge. Accumulating evidence indicates that Lyme disease spirochetes are adapted to persist in immune competent hosts, and that they are able to remain infective despite aggressive antibiotic challenge. Advancing understanding of the survival mechanisms of the Lyme disease spirochete carry noteworthy implications for ongoing research and clinical practice. Keywords: Lyme disease, Borrelia, biofilm, bacterial persistence, antibiotic toleranceKeywords
This publication has 104 references indexed in Scilit:
- Assessment of Polymicrobial Infections in Ticks in New York StateVector-Borne and Zoonotic Diseases, 2010
- Intact Flagellar Motor of Borrelia burgdorferi Revealed by Cryo-Electron Tomography: Evidence for Stator Ring Curvature and Rotor/C-Ring Assembly FlexionJournal of Bacteriology, 2009
- Antibiotic Treatment of Animals Infected withBorrelia burgdorferiClinical Microbiology Reviews, 2009
- Molecular Mechanisms of HipA-Mediated Multidrug Tolerance and Its Neutralization by HipBScience, 2009
- Borrelia burgdorferiGenotype Predicts the Capacity for Hematogenous Dissemination during Early Lyme DiseaseThe Journal of Infectious Diseases, 2008
- The Tick Salivary Protein Salp15 Inhibits the Killing of Serum-Sensitive Borrelia burgdorferi Sensu Lato IsolatesInfection and Immunity, 2008
- Persistence ofBorrelia burgdorferifollowing Antibiotic Treatment in MiceAntimicrobial Agents and Chemotherapy, 2008
- Borrelia burgdorferi Uniquely Regulates Its Motility Genes and Has an Intricate Flagellar Hook-Basal Body StructureJournal of Bacteriology, 2008
- Antibody-Mediated Disease Remission in the Mouse Model of Lyme BorreliosisInfection and Immunity, 2006
- Eukaryotic organisms in Proterozoic oceansPhilosophical Transactions Of The Royal Society B-Biological Sciences, 2006