The Effect of Galanthanine Hydrobromide on Plasma ACTH in Patients Undergoing Anaesthesia and Surgery
- 1 June 1980
- journal article
- Published by Wiley in Acta Anaesthesiologica Scandinavica
- Vol. 24 (3), 166-168
- https://doi.org/10.1111/j.1399-6576.1980.tb01527.x
Abstract
The effects of two anticholinesterases, galanthamine and neostigmine, on ACTH and, in some cases, cortisol were compared in 16 patients undergoing relaxant anaesthesia and surgery for varicose veins. The procedures produced increases both in ACTH and cortisol. Following administration of the study drugs to reverse the non-depolarising neuromuscular block, a statistically significant elevation of ACTH occurred in those patients who received galanthamine. It was concluded, therefore, that the rise in plasma cortisol is ACTH-dependent and not due to a peripheral cholinergic mechanism.Keywords
This publication has 7 references indexed in Scilit:
- Reversal of central anticholinergic syndrome by galanthamineJAMA, 1977
- Galanthamine hydrobromide versus neostigmineAnaesthesia, 1974
- A COMPARATIVE STUDY OF GALANTHAMINE HYDROBROMIDE AND ATROPINE/NEOSTIGMINE IN CONSCIOUS VOLUNTEERSSurvey of Anesthesiology, 1972
- NIVALIN (GALANTHAMINE HYDROBROMIDE), AN ADDITIONAL DECURARIZING AGENT. SOME INTRODUCTORY OBSERVATIONSBritish Journal of Anaesthesia, 1967
- Clinical Experiences with Diallyl-Nor-Toxiferine and the Curare Antidote GalanthamineSouthern Medical Journal, 1966
- Application of the Property of Protein-Binding to the Assay of Minute Quantities of Hormones and Other SubstancesNature, 1964