Chagas disease and the US blood supply
- 1 October 2008
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Infectious Diseases
- Vol. 21 (5), 476-482
- https://doi.org/10.1097/qco.0b013e32830ef5b6
Abstract
To describe new developments in blood-bank screening and management of patients with chronic Trypanosoma cruzi infection in the United States. The first US Food and Drug Administration licensed serological test for T. cruzi blood screening went into widespread usage in January 2007. More than 500 confirmed T. cruzi-infected donations were detected by mid-June 2008. Until recently, drug therapy was recommended for acute and congenital infections, but seldom for chronic infections, which were believed to respond poorly. However, in the 1990s, efficacy was demonstrated in two placebo-controlled trials of benznidazole in children with chronic T. cruzi infection. In 2006, a nonrandomized, nonblinded trial demonstrated that benznidazole treatment may slow progression of cardiomyopathy and decrease mortality risk in infected adults. Blood-bank screening will continue to detect T. cruzi-infected donors. Based on recent data, antitrypanosomal treatment is recommended for all acute and congenital T. cruzi infections, reactivated infection, and chronically infected children. In adults aged 19–50 years without advanced heart disease, treatment should generally be offered; management should be individualized for older adults. Less toxic, more effective drugs, a sensitive, specific assay for response to treatment, and improved healthcare access would promote more effective management.Keywords
This publication has 42 references indexed in Scilit:
- Distribution and characterization of canine Chagas disease in TexasVeterinary Parasitology, 2008
- Predictors of Mortality in Chronic Chagas DiseaseCell Metabolism, 2007
- An update on Chagas disease (human American trypanosomiasis)Pathogens and Global Health, 2006
- Safety of the Blood Supply in Latin AmericaClinical Microbiology Reviews, 2005
- Changing epidemiology and approaches to therapy for Chagas diseaseCurrent Infectious Disease Reports, 2003
- Chagas Disease in a Domestic Transmission Cycle in Southern Texas, USAEmerging Infectious Diseases, 2003
- The impact of Chagas disease control in Latin America: a reviewMemórias do Instituto Oswaldo Cruz, 2002
- SEROPREVALENCE OF TRYPANOSOMA CRUZIIN RACCOONS FROM SOUTH CAROLINA AND GEORGIAJournal of Wildlife Diseases, 2002
- Chagas' Heart DiseaseClinical Cardiology, 2000
- Gastrointestinal manifestations of chagas' diseaseThe American Journal of Gastroenterology, 1998